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Post: EHP Shortcoming in current dose response theoriesPosted by Sharon on 9/22/08
http://www.ehponline.org/members/2008/11502/11502.pdf
"Topics included: the need for formalized approaches and
criteria to assess the evidence for mode of action; the use
of human vs. animal data; the use of mode of action
information in biologically-based models; and the
implications of interindividual variability, background
disease processes and background exposures in threshold vs.
nonthreshold model choice. Approaches that differ from
current practice were recommended for extrapolating high-
dose animal data to low-dose human exposures, including
categorical approaches for integrating information on mode
of action, statistical approaches such as model averaging,
and inference-based models that explicitly consider
uncertainty and interindividual variability."
Over the past half-century, methodological advances have
provided an increasingly strong
quantitative basis for estimating the human health risks
associated with exposures to
environmental contaminants. Estimation of the dose-response
function is one of four critical
elements of the now paradigmatic approach to health risk
assessment developed in 1983 by the
National Research Council (NRC 1983). Establishing dose-
response functions frequently
requires extrapolating limited amounts of data from high-
concentration animal toxicological
studies to the relatively lower concentrations typically
experienced by humans. Statistical
methods, known as “low-dose extrapolation” models, have
been developed for this purpose, and
their merits and limitations have been debated since the
earliest efforts in environmental
contaminant risk assessment.
Posts on this thread, including this one
EHP Shortcoming in current dose response theories, 9/22/08, by Sharon. Re: EHP Shortcoming in current dose response theories, 9/23/08, by Deborah.
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