Re: Tox. and Epi. Evidence for exposure limit setting

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LOL. Love this paper. Pg 847. Think I may soon be using it.

12. Dose-effect and dose-response
relationships
12.1. Dose considerations and extrapolation from animal
studies
Intratracheal and intranasal instillation circumvent the
normal deposition processses in the airways, and distribute
spores deeper into the lung. The dose that reaches the
lung is also increased compared with inhalation. However,
intratracheally instilled dust was less homogeneously
distributed in the lung with little dust reaching the
periphery (Pritchard, 1985). This may lead to local overload
conditions and Pritchard et al. recommended not to
extrapolate doseresponse relationships from animal studies
that applied intratracheal instillation to the human
condition (Pritchard, 1985). Such studies are therefore not
considered further.
In some animal inhalation studies, the applied dose was
estimated by viable counts in lung tissue obtained shortly
(up to 4 hours) after challenge. This method probably
underestimates the applied dose to a large extent and such
studies were also omitted in the dose-effect and dose-response
considerations.

On 12/16/09, Deborah wrote:
> Haven't read it, just saw it.
>
>
> Critical Reviews in Toxicology, 2009; 39(10): 799–864
>
> Fungal spores: A critical review of the toxicological and
> epidemiological evidence as a basis for occupational
> exposure limit setting
>
>
> http://130.88.242.202/medicine/Aspergillus/articlesoverflow
> /fungalsporesreview.pdf