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    Re: New article - mold biotoxins cause non-allergic reaction

    Posted by H on 1/17/10

    Found the abstract through Medscape:

    On 1/15/10, deborah wrote:
    > I still cannot find that article, did find the journal, but not
    > that article.
    > Did find a very interesting one there...
    > Assessment Of Neuromuscular Dysfunction During Poisoning By
    > Organophosphorus Compounds
    > Horst Thiermanna, The Corresponding Author, Thomas Seegera, Sascha
    > Gondera, Nadja Herkerta, Bernd Antkowiakb, Thomas Zilkerc, Florian
    > Eyerc and Franz Woreka
    > Abstract
    > Dysfunction of respiratory muscles is a life-threatening
    > complication in poisoning by organophosphorus compounds (OP). It
    > is both of central and peripheral origin due to impaired
    > cholinergic signalling upon inhibition of acetylcholinesterase
    > (AChE). The dysfunction at neuromuscular synapses is not amenable
    > to anticholinergics and remains a therapeutic challenge. Thus, a
    > clear understanding of the distinct mechanisms occurring at
    > neuromuscular synapses is decisive for the development and
    > improvement of therapeutic strategies, particularly with nerve
    > agent poisoning, where clinical studies are prevented by ethical
    > considerations.
    > On 1/15/10, Deborah wrote:
    >> On 1/11/10, Deborah wrote:
    >>> JF,
    >>> Were you able to find it online somewhere?
    >>> On 1/09/10, Deborah wrote:
    >>>> Thanks!
    >>>> On 1/09/10, JF wrote:
    >>>>> Here's another new article showing non-allergenic health
    >>>>> effects of mold biotoxins. The truth is coming out,
    >>>>> slowly but surely:
    >>>>> Inflammation-associated gene transcription and expression
    >>>>> in mouse lungs induced by low molecular weight compounds
    >>>>> from fungi from the built environment.
    >>>>> J.D. Millera, M. Sunb, A. Gilyanb, J. Royb and T.G. Randb,
    >>>>> Chemico-Biological Interactions
    >>>>> Volume 183, Issue 1, January 2010, Pages 113-124
    >>>>> "The transcriptional regulation in these genes in the
    >>>>> treatment groups suggests that they may serve central
    >>>>> roles in the immunomodulation of toxin-induced pro-
    >>>>> inflammatory lung responses. . . The results further
    >>>>> confirm the inflammatory nature of metabolites/toxins from
    >>>>> such fungi can contribute to the development of non-
    >>>>> allergenic respiratory health effects."

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