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    Post: Hormesis is central to toxicology & risk assessment

    Posted by Sharon on 4/09/10

    Human & Experimental Toxicology
    DOI: 10.1177/0960327109363973
    Hum Exp Toxicol 2010; 29; 249
    Edward J Calabrese
    Hormesis is central to toxicology, pharmacology and risk

    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences
    Division, University of Massachusetts, Amherst, MA, USA,

    This paper summarizes numerous conceptual and experimental
    advances over the past two decades in the study of
    hormesis. Hormesis is now generally accepted as a real and
    reproducible biological phenomenon, being highly
    generalized and independent of biological model, endpoint
    measured and chemical class/physical stressor. The
    quantitative features of the hormetic dose response are
    generally highly consistent, regardless of the model and
    mechanism, and represent a quantitative index of biological
    plasticity at multiple levels of biological organization.
    The hormetic dose-response model has been demonstrated to
    make far more accurate predictions of responses in low dose
    zones than either the threshold or linear at low dose
    models. Numerous therapeutic agents widely used by humans
    are based on the hormetic dose response and its low dose
    stimulatory characteristics. It is expected that as low
    dose responses come to dominate toxicological research that
    risk assessment practices will incorporate hormetic
    concepts in the standard setting process.

    Key Words: hormesis hormetic biphasic U-shaped
    adaptive response inverted U-shaped

    Human & Experimental Toxicology, Vol. 29, No. 4, 249-261
    DOI: 10.1177/0960327109363973

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