Post: Relationshipsrhinitis, fibromyalgia, and chronic fatigue
Posted by Sharon on 6/21/10
Relationships among rhinitis, fibromyalgia, and chronic
fatigue
http://www.ingentaconnect.com/content/ocean/aap/2010/0000003
1/00000003/art00002
Authors: Baraniuk, James N.; Zheng, Yin
Source: Allergy and Asthma Proceedings, Volume 31, Number
3, May/June 2010 , pp. 169-178(10)
Publisher: OceanSide Publications, Inc
Allergy and Asthma Proceedings is a peer reviewed
publication dedicated to distributing timely scientific
research regarding advancements in the knowledge and
practice of allergy, asthma and immunology. Its primary
readership consists of allergists and pulmonologists.
The goal of the Proceedings is to publish articles with a
predominantly clinical focus which directly impact quality
of care for patients with allergic disease and asthma.
Featured topics include asthma, rhinitis, sinusitis, food
allergies, allergic skin diseases, diagnostic techniques,
allergens, and treatment modalities. Published material
includes peer-reviewed original research, clinical trials
and review articles.
Abstract:
New information about the pathophysiology of idiopathic
nonallergic rhinopathy indicates a high prevalence in
chronic fatigue syndrome (CFS). This article shows the
relevance of CFS and allied disorders to allergy practice.
CFS has significant overlap with systemic hyperalgesia
(fibromyalgia), autonomic dysfunction (irritable bowel
syndrome and migraine headaches), sensory hypersensitivity
(dyspnea; congestion; rhinorrhea; and appreciation of
visceral nociception in the esophagus, gastrointestinal
tract, bladder, and other organs), and central nervous
system maladaptations (central sensitization) recorded by
functional magnetic resonance imaging (fMRI). Neurological
dysfunction may account for the overlap of CFS with
idiopathic nonallergic rhinopathy. Scientific advances are
in fMRI, nociceptive sensor expression, and, potentially,
infection with xenotropic murine leukemia-related virus
provide additional insights to novel pathophysiological
mechanisms of the “functional” complaints of these patients
that are mistakenly interpreted as allergic syndromes. As
allergists, we must accept the clinical challenges posed by
these complex patients and provide proper diagnoses,
assurance, and optimum care even though current treatment
algorithms are lacking.
Keywords: Central sensitization; CFS; chronic fatigue
syndrome; dysautonomia; fatigue; fibromyalgia; idiopathic
nonallergic rhinitis; pain; xenotropic murine leukemia-
related virus; XMRV
Document Type: Research article
DOI: 10.2500/aap.2010.31.3311
Posts on this thread, including this one