Post: 2, 3-DPG and nitric oxide
Posted by Pat on 4/09/03
Before I posted on Dilnaz's discovery that MCS sufferers
have excess 2,3-DPG enzymes due to extreme oxygen deprivation.
As I've also posted b4, Martin Pall put forth the theory of
NO. poisoning as the etiology of MCS. I contacted Martin
Pall and asked him how nitric oxide (NO) could explain the
2, 3-DPG excess. He wrote, "Nitric oxide binds to heme
groups just as does carbon monoxide. Having said that, I
would think that there are other, more plausible mechanisms
by which nitric oxide might produce increases in 2,3-DPG
including the vasodilatation produced by nitric oxide,
leading to increased pooling of blood in the lower parts of
the body and decreased perfusion in other tissues."
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