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    Re: Hey Pat: About nitric oxide

    Posted by Pat on 4/29/03

    Hey, how r ya?

    That is a good question and at present I'm not sure. I think more
    research should take place before any conclusions are drawn.

    The data on MCS's origins and mechanisms is overwhelming. For example,
    Albert Donnay has a competing theory a CO poisoning as a cause of
    chemical sensitivity. Excessive levels of CO will increase levels of
    NO via iNOS. "Marty?s theory is just one little slice of what CO
    poisoning does to people", said Donnay,

    Interestingly, stresses of all kind (emotional, chemical, etc)
    increase CO levels via HO-1. This could explain why emotional stress
    often heightens sensitivity in sufferers.

    However, the genetic data point more to a NO etiology. I think the two
    work together to certain degrees depending on the case.

    The NO/CO pathways should definitely be the focus of research.

    I think that until more data are collected, the answer to your
    question would have to be speculative and I don't like speculation.

    Take care,

    ~ Pat

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