Re: Blood-brain barrier

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just come across your site .If your a researcher you may find the
research being done in scotland of interest . The M.E./CFS
RESEARCH SITE can be found at www.meresearch.org.uk

On 9/12/03, Pat wrote:
> His name is Martin Pall, a WSU Biochemist who is very
intelligent.
> I have often corresponded with him. He is such a nice guy!
>
> His phone number is 509-335-1246, and his email address is
> martin_pall@wsu.edu
>
> Pall's theory is a fusion of two prior theories: The theory of
> neural sensitization and his own theory that NO/and its oxidant
> product induce MCS when elevated in the body. Neural
> sensitization, Pall explains, says "that the synapses in the
> brain, the connections between nerve cells by which one nerve
cell
> stimulates (or in some cases inhibits) another become
> hypersensitive in MCS. This neural sensitization theory is
> supported by observations that many of the symptoms of MCS relate
> directly to brain function and that a number of studies have
shown
> that scans of the brains of MCS people, performed by techniques
> known as PET scanning or SPECT scanning are abnormal. There is
> also evidence that electrical activity in the brains of MCS
> people, measured by EEG's, is also abnormal. Neural sensitization
> is produced by a mechanism known as long term potentiation, a
> mechanism that has a role in learning and memory. Long term
> potentiation produces neural sensitization but in the normal
> nervous system, it does so very selectively - increasing the
> sensitivity of certain selected synapses. In MCS, it may be
> suggested, that a widespread sensitization may be involved that
is
> somehow triggered by chemical or pesticide exposure." ~ Taken
from
> http://molecular.biosciences.wsu.edu/Faculty/pall/pall_mcs.htm
>
> I have included Pall's theory, plus the evidence for it in a
> recent paper I wrote, which is currently being reviewed by
> Nicholas Ashford.
>
> Pall's essay (linked to above) discusses the blood-brain barrier
> and its relationship to MCS.
>
> As was the case nearly a decade ago, there is just too much
> evidence for honest, objective skepticism to remain. "Skepticism"
> remains for reasons other than objectivity.
>
> ~ Pat
>
>
>
> On 9/06/03, jenny wrote:
>> Yes--there is research even done by someone in washington
>> state who claims something very similar to this, including
>> increases of NO--nitric oxide. My sister is a medical student
>> at mayo and she is trying to get more information on this, and
>> plans to contact this professor or try to start a research
>> program regarding this, since there are no resources for people
>> with this condition. In the mean time, we need to educate
>> others about mcs, because I find it appalling that this stupid
>> society believes it's psychogenic. So far they also believed
>> fibro, cfs, asthma, and ms were psychogenic. Well they need to
>> learn from their mistakes --- it's unfair that people with mcs
>> have to suffer like this with no hope and no solution...

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