Re: Blood-brain barrier
Posted by Pat on 9/12/03
His name is Martin Pall, a WSU Biochemist who is very intelligent.
I have often corresponded with him. He is such a nice guy!
His phone number is 509-335-1246, and his email address is
Pall's theory is a fusion of two prior theories: The theory of
neural sensitization and his own theory that NO/and its oxidant
product induce MCS when elevated in the body. Neural
sensitization, Pall explains, says "that the synapses in the
brain, the connections between nerve cells by which one nerve cell
stimulates (or in some cases inhibits) another become
hypersensitive in MCS. This neural sensitization theory is
supported by observations that many of the symptoms of MCS relate
directly to brain function and that a number of studies have shown
that scans of the brains of MCS people, performed by techniques
known as PET scanning or SPECT scanning are abnormal. There is
also evidence that electrical activity in the brains of MCS
people, measured by EEG's, is also abnormal. Neural sensitization
is produced by a mechanism known as long term potentiation, a
mechanism that has a role in learning and memory. Long term
potentiation produces neural sensitization but in the normal
nervous system, it does so very selectively - increasing the
sensitivity of certain selected synapses. In MCS, it may be
suggested, that a widespread sensitization may be involved that is
somehow triggered by chemical or pesticide exposure." ~ Taken from
I have included Pall's theory, plus the evidence for it in a
recent paper I wrote, which is currently being reviewed by
Pall's essay (linked to above) discusses the blood-brain barrier
and its relationship to MCS.
As was the case nearly a decade ago, there is just too much
evidence for honest, objective skepticism to remain. "Skepticism"
remains for reasons other than objectivity.
On 9/06/03, jenny wrote:
> Yes--there is research even done by someone in washington
> state who claims something very similar to this, including
> increases of NO--nitric oxide. My sister is a medical student
> at mayo and she is trying to get more information on this, and
> plans to contact this professor or try to start a research
> program regarding this, since there are no resources for people
> with this condition. In the mean time, we need to educate
> others about mcs, because I find it appalling that this stupid
> society believes it's psychogenic. So far they also believed
> fibro, cfs, asthma, and ms were psychogenic. Well they need to
> learn from their mistakes --- it's unfair that people with mcs
> have to suffer like this with no hope and no solution...
Posts on this thread, including this one