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Re: Dr. Ritchie Shoemaker
Posted by Cindy Fulghum on 4/13/07

    On 1/04/05, Greg Weatherman wrote:
    > For those interested,
    >
    > The research done by Dr. Ritchie Shoemaker (private physician), Dr.
    > Ken Hudnell (EPA neurotoxicologist) and Dennis House (Retired EPA
    > Statitician)has finally been published in a peer reviewed, scientific
    > journal (for Daubert examination purposes). Now that the light switch
    > has been turned "on", we'll see the cockroaches scurry for cover in
    > the darkness. I hear someone very prominent is listed as a reviewer.
    > I have inserted a link at the bottom of the page for anyone who wants
    > to purchase the article to read:
    >
    > Neurotoxicology and Teratology
    >
    > A time-series study of sick building syndrome: chronic, biotoxin-
    > associated illness from exposure to water-damaged buildings
    >
    > Ritchie C. Shoemaker a, b, and Dennis E. House b
    >
    > a Chronic Fatigue Center, 500 Market Street, Suite 103, Pocomoke City,
    > MD 21851, United States
    >
    > b Center for Research on Biotoxin-Associated Illness, 500 Market
    > Street, Suite102, Pocomoke City, MD 21851, United States
    >
    > Received 6 April 2004; revised 30 July 2004; accepted 30 July 2004.
    > Available online 13 September 2004.
    >
    > Abstract
    >
    > The human health risk for chronic illnesses involving multiple body
    > systems following inhalation exposure to the indoor environments of
    > water-damaged buildings (WDBs) has remained poorly characterized and
    > the subject of intense controversy. The current study assessed the
    > hypothesis that exposure to the indoor environments of WDBs with
    > visible microbial colonization was associated with illness. The study
    > used a cross-sectional design with assessments at five time points,
    > and the interventions of cholestyramine (CSM) therapy, exposure
    > avoidance following therapy, and reexposure to the buildings after
    > illness resolution. The methodological approach included oral
    > administration of questionnaires, medical examinations, laboratory
    > analyses, pulmonary function testing, and measurements of visual
    > function. Of the 21 study volunteers, 19 completed assessment at each
    > of the five time points. Data at Time Point 1 indicated multiple
    > symptoms involving at least four organ systems in all study
    > participants, a restrictive respiratory condition in four
    > participants, and abnormally low visual contrast sensitivity (VCS) in
    > 18 participants. Serum leptin levels were abnormally high and alpha
    > melanocyte stimulating hormone (MSH) levels were abnormally low.
    > Assessments at Time Point 2, following 2 weeks of CSM therapy,
    > indicated a highly significant improvement in health status.
    > Improvement was maintained at Time Point 3, which followed exposure
    > avoidance without therapy. Reexposure to the WDBs resulted in illness
    > reacquisition in all participants within 1 to 7 days. Following
    > another round of CSM therapy, assessments at Time Point 5 indicated a
    > highly significant improvement in health status. The group-mean number
    > of symptoms decreased from 14.9±0.8 S.E.M. at Time Point 1 to 1.2±0.3
    > S.E.M., and the VCS deficit of approximately 50&37; at Time Point 1 was
    > fully resolved. Leptin and MSH levels showed statistically significant
    > improvement. The results indicated that CSM was an effective
    > therapeutic agent, that VCS was a sensitive and specific indicator of
    > neurologic function, and that illness involved systemic and
    > hypothalamic processes. Although the results supported the general
    > hypothesis that illness was associated with exposure to the WDBs, this
    > conclusion was tempered by several study limitations. Exposure to
    > specific agents was not demonstrated, study participants were not
    > randomly selected, and double-blinding procedures were not used.
    > Additional human and animal studies are needed to confirm this
    > conclusion, investigate the role of complex mixtures of bacteria,
    > fungi, mycotoxins, endotoxins, and antigens in illness causation, and
    > characterize modes of action. Such data will improve the assessment of
    > human health risk from chronic exposure to WDBs.
    >
    > Regards,
    >
    > Greg Weatherman
    > aerobioLogical Solutions Inc.
    > Arlington VA 22202
    >
    > gw@aerobiological.com
    >
    >


     
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