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    Re: MCS brought on by toxid mold

    Posted by ff on 10/14/04

    Angie -

    I think Mary gave you some good advice, and as far as the insults, you
    should have been posting a year ago when the Wrath of Mary was common.

    Basically, we/you may sound irrational, and we need to take a hard look
    at that. If you want to prent the issue, I say drop phrases like get-a-
    piece-of-the-pie, crazy, hypochondriac, i.e. present your case in a way
    that gives credibility to what you say (I say this, realizing that I
    may be an offender as well).


    On 10/13/04, Angie wrote:
    > Hi all. I don't know who Sharon is. I am Angie and new to the
    > board. All I meant by "get a piece of the pie," is that you should be
    > willing to educate yourself about toxic mold and its effects for the
    > sake of understanding victims and also for prevention. If you are
    > hard hearted enough to not do it for those reasons, and are willing
    > to learn more in order to take on more cases (for business purposes,)
    > then do it. I don't care why you educate yourself, just do it. I
    > say this with confidence because I believe that regardless to your
    > motives for learning more about toxic mold, you will learn more and
    > become more sensitive to victims and their needs. I believe that as
    > public awareness and proof grows, you'll finally resign yourself to
    > believing that toxic mold causes illness.
    > Mary, I'm not trying to sound harsh or irrational. I'm speaking from
    > my experience. After all, isn't that all we truly know? I know
    > you're not here to make friends, but your tone and responses have
    > been very insensitive to those who know first hand what this mold can
    > do. If I sound overly sensitive, I am. It's because I've had to try
    > to convince people for the last few years that I'm not crazy. That
    > my symptoms aren't psychosymatic. I never wanted to believe that my
    > house could be making me sick. I didn't make this stuff up. You
    > think I want to look crazy to people? I'm not a hypochondriac. I
    > believe that my family will get better. I believe that someday there
    > will be a treatment for the conditions we all now have.
    > Hypochondriacs don't wish to get better. I do. If you were to poll
    > hundreds of mold victims from around the country that have never met,
    > you'd find that we all share similar symptoms and diseases. While
    > some symptoms vary, there is a very common list of symptoms that we
    > share. If we have never met or talked to one another, but the one
    > trauma we all share is exposure to toxic mold, and we all share a
    > common list of symptoms, how can we all be making it up?
    > I am sharing this information in hopes to educate people. My wish is
    > to not insult anyone. Everyone is entitled to their opinion,
    > including you Mary. I just want to squelch the lack of compassion
    > and insensitive comments that so many victims have to continually
    > hear from "so called" professional people that know nothing, nor take
    > the time to learn anything about their situation. So please take
    > what I share and learn about it.
    > I truly pray that none of you ever have to experience what my family
    > has experienced. We were a family full of dreams and aspirations for
    > one another. My 2 children are very artistically talented and were
    > accepted into a prestigous art school. Their education has now been
    > greatly hindered due to their health problems and everyday has become
    > a constant struggle to keep them motivated and encouraged. They have
    > given up. So understand that this isn't about me. It's about
    > thousands of innocent children out there. School children that are
    > being exposed to moldy schools, teachers being made ill, and adults
    > that are great contributors to society that are suddently taken from
    > our work force and disabled. It's not as small as my family, it's a
    > grave injustice to our entire nation and our nation's future.
    > Here are some scientific studies that you may find helpful. There
    > are a lot of good books out there, but there are a lot of quacks
    > also. The only book I truly recommend for good evidence is "Mold &
    > Mycotoxins," by Dr. Kaye H. Kilburn, M.D.
    > She worked very closely with Dr. Dorr Dearborn (Case Western
    > University/Children's Hospital, Cleveland, Ohio)who is famous for
    > finding a link between pulmonary hemorrage in infants and mold
    > exposure. Both are reknowned for their work in the area of mold
    > treatment and studies.
    > I have a copy of the testimony Dr. Stephen C. Redd, from the CDC and
    > The Department of Health and Human Services gave before Congress
    > saying that mold can cause health problems. I would be happy to send
    > it to anyone that is interested. These studies may be difficult to
    > read and very lengthy. I would love to pass them on to anyone that
    > would like to have copies. Anyone that wants to contact me can email
    > me at Thank you for taking the time to
    > read this.
    > Angie
    > Indoor mold exposure associated with neurobehavioral and
    > pulmonary impairment: a preliminary report
    > by PubMed
    > Kilburn KH.
    > University of Southern California, Keck School of Medicine,
    > Environmental Sciences
    > Laboratory, Alhambra, California 91803, USA.
    > Recently, patients who have been exposed indoors to mixed molds,
    > spores, and
    > mycotoxins have reported asthma, airway irritation and bleeding,
    > dizziness, and
    > impaired memory and concentration, all of which suggest the presence
    > of pulmonary
    > and neurobehavioral problems. The author evaluated whether such
    > patients had
    > measurable pulmonary and neurobehavioral impairments by comparing
    > consecutive
    > cases in a series vs. a referent group. Sixty-five consecutive
    > outpatients exposed to
    > mold in their respective homes in Arizona, California, and Texas were
    > compared with
    > 202 community subjects who had no known mold or chemical exposures.
    > Balance,
    > choice reaction time, color discrimination, blink reflex, visual
    > fields, grip, hearing,
    > problem-solving, verbal recall, perceptual motor speed, and memory
    > were
    > measured. Medical histories, mood states, and symptom frequencies
    > were recorded
    > with checklists, and spirometry was used to measure various pulmonary
    > volumes
    > and flows. Neurobehavioral comparisons were made after individual
    > measurements
    > were adjusted for age, educational attainment, and sex. Significant
    > differences
    > between groups were assessed by analysis of variance; a p value of
    > less than 0.05
    > was used for all statistical tests. The mold-exposed group exhibited
    > decreased
    > function for balance, reaction time, blink-reflex latency, color
    > discrimination, visual
    > fields, and grip, compared with referents. The exposed group's scores
    > were reduced
    > for the following tests: digit-symbol substitution, peg placement,
    > trail making, verbal
    > recall, and picture completion. Twenty-one of 26 functions tested
    > were abnormal.
    > Airway obstructions were found, and vital capacities were reduced.
    > Mood state scores
    > and symptom frequencies were elevated. The author concluded that
    > indoor mold
    > exposures were associated with neurobehavioral and pulmonary
    > impairments that
    > likely resulted from the presence of mycotoxins, such as
    > trichothecenes.
    > Publication Types:
    > • Clinical Trial
    > • Controlled Clinical Trial
    > • Randomized Controlled Trial
    > PMID: 15143851 [PubMed - indexed for MEDLINE]
    > *********************************************************
    > 1: Arch Environ Health. 2003 Aug;58(8):464-74. Related
    > Links
    > Neural autoantibodies and neurophysiologic abnormalities in patients
    > exposed to molds in water-damaged buildings.
    > Campbell AW, Thrasher JD, Madison RA, Vojdani A, Gray MR, Johnson A.
    > Medical Center for Immune and Toxic Disorders, Spring, Texas 77386,
    > USA.
    > Adverse health effects of fungal bioaerosols on occupants of water-
    > damaged homes and other buildings have been reported. Recently, it
    > has been suggested that mold exposure causes neurological injury. The
    > authors investigated neurological antibodies and neurophysiological
    > abnormalities in patients exposed to molds at home who developed
    > symptoms of peripheral neuropathy (i.e., numbness, tingling, tremors,
    > and muscle weakness in the extremities). Serum samples were collected
    > and analyzed with the enzyme-linked immunosorbent assay (ELISA)
    > technique for antibodies to myelin basic protein, myelin-associated
    > glycoprotein, ganglioside GM1, sulfatide, myelin oligodendrocyte
    > glycoprotein, alpha-B-crystallin, chondroitin sulfate, tubulin, and
    > neurofilament. Antibodies to molds and mycotoxins were also
    > determined with ELISA, as reported previously. Neurophysiologic
    > evaluations for latency, amplitude, and velocity were performed on 4
    > motor nerves (median, ulnar, peroneal, and tibial), and for latency
    > and amplitude on 3 sensory nerves (median, ulnar, and sural).
    > Patients with documented, measured exposure to molds had elevated
    > titers of antibodies (immunoglobulin [Ig]A, IgM, and IgG) to neural-
    > specific antigens. Nerve conduction studies revealed 4 patient
    > groupings: (1) mixed sensory-motor polyneuropathy (n = 55, abnormal),
    > (2) motor neuropathy (n = 17, abnormal), (3) sensory neuropathy (n =
    > 27, abnormal), and (4) those with symptoms but no neurophysiological
    > abnormalities (n = 20, normal controls). All groups showed
    > significantly increased autoantibody titers for all isotypes (IgA,
    > IgM, and IgG) of antibodies to neural antigens when compared with 500
    > healthy controls. Groups 1 through 3 also exhibited abnormal
    > neurophysiologic findings. The authors concluded that exposure to
    > molds in water-damaged buildings increased the risk for development
    > of neural autoantibodies, peripheral neuropathy, and neurophysiologic
    > abnormalities in exposed individuals.
    > PMID: 15259425 [PubMed - indexed for MEDLINE]
    > ********************************************************
    > Show:
    > 1: Arch Environ Health. 2003 Aug;58(8):452-63. Related
    > Links
    > Psychological, neuropsychological, and electrocortical effects of
    > mixed mold exposure.
    > Crago BR, Gray MR, Nelson LA, Davis M, Arnold L, Thrasher JD.
    > Neurobehavioral Health Services, Tucson, Arizona 85712, USA.
    > The authors assessed the psychological, neuropsychological, and
    > electrocortical effects of human exposure to mixed colonies of
    > toxigenic molds. Patients (N = 182) with confirmed mold-exposure
    > history completed clinical interviews, a symptom checklist (SCL-90-
    > R), limited neuropsychological testing, quantitative
    > electroencephalogram (QEEG) with neurometric analysis, and measures
    > of mold exposure. Patients reported high levels of physical,
    > cognitive, and emotional symptoms. Ratings on the SCL-90-R
    > were "moderate" to "severe," with a factor reflecting situational
    > depression accounting for most of the variance. Most of the patients
    > were found to suffer from acute stress, adjustment disorder, or post-
    > traumatic stress. Differential diagnosis confirmed an etiology of a
    > combination of external stressors, along with organic metabolically
    > based dysregulation of emotions and decreased cognitive functioning
    > as a result of toxic or metabolic encephalopathy. Measures of toxic
    > mold exposure predicted QEEG measures and neuropsychological test
    > performance. QEEG results included narrowed frequency bands and
    > increased power in the alpha and theta bands in the frontal areas of
    > the cortex. These findings indicated a hypoactivation of the frontal
    > cortex, possibly due to brainstem involvement and insufficient
    > excitatory input from the reticular activating system.
    > Neuropsychological testing revealed impairments similar to mild
    > traumatic brain injury. In comparison with premorbid estimates of
    > intelligence, findings of impaired functioning on multiple cognitive
    > tasks predominated. A dose-response relationship between measures of
    > mold exposure and abnormal neuropsychological test results and QEEG
    > measures suggested that toxic mold causes significant problems in
    > exposed individuals. Study limitations included lack of a comparison
    > group, patient selection bias, and incomplete data sets that did not
    > allow for comparisons among variables.
    > PMID: 15259424 [PubMed - indexed for MEDLINE]
    > ****************************************************
    > 1: ScientificWorldJournal. 2003 Nov 3;3:1058-64. Print 2003 Nov 3.
    > Related Articles, Links
    > Biochemical changes in the serum of patients with chronic toxigenic
    > mold exposures: a risk factor for multiple renal dysfunctions.
    > Anyanwu E, Campbell AW, Vojdani A, Ehiri JE, Akpan AI.
    > Neurosciences Research, Cahers Inc., Conroe, TX, USA.
    > This paper analyzes and presents the biochemical abnormalities in the
    > sera of patients presenting with chronic mycosis in order to
    > investigate the relationship with the risks of multiple renal
    > disorders. The study population (n = 10) consisted of six females and
    > four males (mean age 36.3 years) exposed by toxic molds in their
    > homes and offices for an average of 2.8 years. The control group
    > comprised ten people, five males and five females (mean age 35.9
    > years) without any known exposures to toxic molds. Blood samples were
    > obtained from both the patients and the controls and were processed
    > using specific biochemical methods that included enzyme-linked
    > immunoabsorbent assay (ELISA). There were biochemical abnormal
    > concentrations in creatinine, uric acid, phosphorus, alkaline
    > phosphotase, cholesterol, HDH, SGOT/AST, segmented neutrophils,
    > lymphocytes, total T3, IgG and IgA immunoglobulins with significant
    > differences between patients and controls. These abnormalities were
    > consistent with multiple renal disorders. The major complaints of the
    > mycosis patients were headaches, pulmonary symptoms, allergic
    > reactions, memory loss, skin rashes, blurred vision symptoms,
    > fatigue, and runny nose. These findings were depictive of a strong
    > association of chronic mycosis with abnormal renal indicators. It was
    > concluded that, although this research was a pilot investigation,
    > based on the overall results, people exposed to chronic indoor
    > environmental toxic molds were at risk of multiple renal
    > complications.
    > PMID: 14612611 [PubMed - indexed for MEDLINE]
    > *****************************************************
    > 1: Arch Environ Health. 2003 Jul;58(7):442-6. Related Articles,
    > Links
    > Health symptoms caused by molds in a courthouse.
    > Lee TG.
    > Faculty of Environmental Design, The University of Calgary, Calgary,
    > Alberta, Canada.
    > A majority of occupants of a newly renovated historic courthouse in
    > Calgary, Alberta, Canada, reported multiple (3 or more) health-
    > related symptoms, and several reported more than 10 persistent
    > symptoms. Most required at least 1 day outside of the building to
    > recover from their symptoms. Molds that produce mycotoxins, such as
    > Stachybotrys chartarum and Emericella nidulans, were identified in
    > the building, along with fungal organisms of the genera Aspergillus,
    > Penicillium, Streptomyces, Cladosporium, Chaetomium, Rhizopus/Mucor,
    > Alternaria, Ulocladium, and Basidiomycetes. Renovations to this
    > historic had building failed to provide adequate thermal and vapor
    > barriers, thus allowing moist indoor air to migrate into the building
    > enclosure, causing condensation to develop. Mold grew on the
    > condensation and was dispersed throughout the courthouse, including
    > on furniture and files. The courthouse was closed and a new facility
    > was modified with low-offgassing materials, better ventilation and
    > air filtration, and strict building maintenance to accommodate those
    > occupants of the older building who had developed multiple chemical
    > sensitivities.
    > PMID: 15143857 [PubMed - indexed for MEDLINE]
    > **************************************************
    > Abstract: Identifying markers for chronic illness in pediatric
    > patients exposed to water damaged buildings: Linkage disequilibrium
    > of HLA DR, MSH, MMP9 and autoantibodies
    > Authors: Ritchie C. Shoemaker¹, Courtney Holt¹, Dennis House¹, HK
    > Hudnell²
    > ¹Center for Research on Biotoxin Associated Illnesses, Pocomoke, Md;
    > ²US EPA NHEERL, Research Triangle Park, NC
    > Background: No studies have previously identified biomarkers
    > adequate to create a case definition of illness associated with
    > exposure to water damaged buildings (WDB) in pediatric patients.
    > Previous work from this facility has presented a case definition of
    > illness in adults that includes exposure, symptoms and absence of
    > confounders, together with biomarkers HLA DR genotypes of the immune
    > response genes; deficiency of the hypothalamic immunomodulatory
    > hormone, alpha melanocyte stimulating hormone (MSH); excess pro-
    > inflammatory cytokine responses, represented by matrix
    > metalloproteinase-9 (MMP9), deficits in visual contrast and pituitary
    > hormone dysregulation. We have seen an increased incidence of
    > antibodies to gliadin, cardiolipin and myelin basic protein in adults
    > with chronic illness following exposure to WDB. Here we present data
    > supporting a pediatric case definition using multiple biomarkers from
    > 66 patients with illness following exposure to WDB.
    > Methods: Patients under age 19 coming for treatment of chronic
    > illness at a specialized medical clinic provided informed consent for
    > evaluation and blood testing prior to initiation of definitive
    > therapy for presumptive chronic, biotoxin associated illness.
    > Symptoms were recorded and blood was sent to national high complexity
    > labs for analysis of HLA DR genotype, MSH, MMP9, anticardiolipins
    > (ACLA), antigliadins (AGA) and myelin basic protein (MBP) antibodies.
    > Lab parameters were compared to in-house registries of control
    > patients and published registries. Following treatment and
    > confirmation of diagnosis, cases were then analyzed by biomarker to
    > identify unique diagnostic features.
    > Results: Control populations have markedly different HLA DR genotype
    > distributions from cases, with relative risks for illness identified
    > for the same genotypes as reported previously in adults. Affected
    > patients had lower levels of MSH and MMP9 than controls. Marked
    > increase in incidence of antibodies to antigliadin IgG,
    > anticardiolipin IgM and myelin basic protein antibodies was found in
    > affected patients compared to controls. Taken together, the
    > combination of potential for exposure, absence of confounding
    > diagnoses, presence of distinctive groupings of symptoms, including
    > fatigue and cognitive problems identified over 85&37; of cases.
    > HLA DR, MSH deficiency, AGA-IgG and ACLA-IgM increased the case
    > detection rate to 100&37;. For patients with MMP9 over 400, HLA DR
    > MSH deficiency alone identified all cases.
    > Conclusion: Specific genetic, physiologic and neurotoxicologic
    > factors can be identified in pediatric patients that identify cases
    > of chronic illness due to exposure to WDB. Physiologic mechanisms
    > associated with increased production of particular autoantibodies
    > will require further study.

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