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    Re: MCS brought on by toxid mold

    Posted by Jeanine Moseley on 11/25/05

    On 1/30/05, Sandra Tyson wrote:
    > January 31st. 2005
    > I am writing because for the past 9 and 1/2 yrs, ive been suffering from mold
    > poisioning. This lead to End stage Renal Failure and ive been scratching
    > myself into oblivion everyday. My life gets worse everyday and complications
    > are endless. My renal physicians have given me various reasons for my
    > problems. I need a pychoanalyst - its in my head and given me medicines for
    > depression. Its my other health complications causing the itching and
    > various other problems. My phosphorous is too high and thats why I itch so
    > much. No medicines help. I've soaked in any and all solutions with the
    > exception of gasoline, trying to get the itching to stop, but to no avail.
    > My skin is a mass of broken, torn tissue from the constant scratching. With
    > every operation that I have, I develop internal infections that manifests
    > themselves in lumps or pockets that need to be removed surgically and then
    > left open and needing to be cleaned out daily and stuffed, but there is
    > always some infection roaming around my body. I itch so much that i cant go
    > out in public at times, I can't stay still for Dialysis for my allotted time,
    > any operations unless anesthesia is administered, no tests nor procedures can
    > be conducted where i have to stay still. It feels like something is either
    > walking, sticking or laying on my skin and if i try to ignore it, the
    > molestation continues and gets worse. My hair feels like its being plucked
    > out, my skin cells pop off of me, things just drop in my eyes and their is
    > always something wrong with my eyesight, I cant see clearly and there is
    > always something gathering in the wells of my tear ducts. The optomotrist
    > says its because ive reached the 40 yr mark. My doctors think that im
    > crazy. They've sent me to dermatologists, who declare they don't know whats
    > wrong with me, just extremely dry skin. I cry all the time to think and see
    > what has happened to me. I've even tried contacting the Infectious disease
    > doctors and they also don't know what i'm talking about. Once I contacted
    > the CDC, it took them over a month to send someone out to my apartment to
    > check it out - she said the house was covered in mold and would contact the
    > owner, but I couldn't live there anymore, after 14 years - I had to move.
    > But the problem still continues, I live in Florida, hurricanes, rain,
    > humidity bad building supplies, etc, etc, etc. I don't know what else to do,
    > I sometimes think that I'm going crazy.
    > Sandra,
    > On 12/17/04, ff wrote:
    >> CW:
    >> I read your post, and certainly you are entitled to your opinion. Without
    >> further discussion, you are simply wrong, very wrong. You apparently don't
    >> have enough knowledge to know how wrong you are.
    >> ff
    >> On 12/15/04, C. Williams wrote:
    >>> Folks:
    >>> I've heard Shoomaker speak and this guy is a "true-believer" a
    >>> real "kool-aid drinker". I really don't know where the truth lies in
    >>> all this, but listening to him makes me think of him more as a saleman
    >>> more than a doc. Oh yeah, did you know he has *another* book out for
    >>> sale? That makes #5.
    >>> One that that really got me interested is that, when he went through his
    >>> presentation, he gave a forceful discussion of the tests he used to
    >>> determine that his patients were victims of mold biotoxicity. Well, it
    >>> just so happens that all these tests were individually used to test for
    >>> some other condition originally. In the end, you can basically make
    >>> them say what you want them to say if they are being used for something
    >>> never intended.
    >>> Seems to me that the whole problem. Shoomaker is emblematic of the
    >>> growth industry characterized by "expert witnesses", plaintiffs'
    >>> lawyers, remediators, etc... that are determined to make a buck off of
    >>> something that we really still know very little about.
    >>> Everybody needs to be very careful about what they read and believe.
    >>> There is a lot of snake oil out there right now.
    >>> CW
    >>> On 10/14/04, dd wrote:
    >>>> Angie,
    >>>> Thank you for sharing the fruit of your research.
    >>>> dd
    >>>> On 10/13/04, Angie wrote:
    >>>>> Hi all. I don't know who Sharon is. I am Angie and new to the
    >>>>> board. All I meant by "get a piece of the pie," is that you should be
    >>>>> willing to educate yourself about toxic mold and its effects for the
    >>>>> sake of understanding victims and also for prevention. If you are
    >>>>> hard hearted enough to not do it for those reasons, and are willing
    >>>>> to learn more in order to take on more cases (for business purposes,)
    >>>>> then do it. I don't care why you educate yourself, just do it. I
    >>>>> say this with confidence because I believe that regardless to your
    >>>>> motives for learning more about toxic mold, you will learn more and
    >>>>> become more sensitive to victims and their needs. I believe that as
    >>>>> public awareness and proof grows, you'll finally resign yourself to
    >>>>> believing that toxic mold causes illness.
    >>>>> Mary, I'm not trying to sound harsh or irrational. I'm speaking from
    >>>>> my experience. After all, isn't that all we truly know? I know
    >>>>> you're not here to make friends, but your tone and responses have
    >>>>> been very insensitive to those who know first hand what this mold can
    >>>>> do. If I sound overly sensitive, I am. It's because I've had to try
    >>>>> to convince people for the last few years that I'm not crazy. That
    >>>>> my symptoms aren't psychosymatic. I never wanted to believe that my
    >>>>> house could be making me sick. I didn't make this stuff up. You
    >>>>> think I want to look crazy to people? I'm not a hypochondriac. I
    >>>>> believe that my family will get better. I believe that someday there
    >>>>> will be a treatment for the conditions we all now have.
    >>>>> Hypochondriacs don't wish to get better. I do. If you were to poll
    >>>>> hundreds of mold victims from around the country that have never met,
    >>>>> you'd find that we all share similar symptoms and diseases. While
    >>>>> some symptoms vary, there is a very common list of symptoms that we
    >>>>> share. If we have never met or talked to one another, but the one
    >>>>> trauma we all share is exposure to toxic mold, and we all share a
    >>>>> common list of symptoms, how can we all be making it up?
    >>>>> I am sharing this information in hopes to educate people. My wish is
    >>>>> to not insult anyone. Everyone is entitled to their opinion,
    >>>>> including you Mary. I just want to squelch the lack of compassion
    >>>>> and insensitive comments that so many victims have to continually
    >>>>> hear from "so called" professional people that know nothing, nor take
    >>>>> the time to learn anything about their situation. So please take
    >>>>> what I share and learn about it.
    >>>>> I truly pray that none of you ever have to experience what my family
    >>>>> has experienced. We were a family full of dreams and aspirations for
    >>>>> one another. My 2 children are very artistically talented and were
    >>>>> accepted into a prestigous art school. Their education has now been
    >>>>> greatly hindered due to their health problems and everyday has become
    >>>>> a constant struggle to keep them motivated and encouraged. They have
    >>>>> given up. So understand that this isn't about me. It's about
    >>>>> thousands of innocent children out there. School children that are
    >>>>> being exposed to moldy schools, teachers being made ill, and adults
    >>>>> that are great contributors to society that are suddently taken from
    >>>>> our work force and disabled. It's not as small as my family, it's a
    >>>>> grave injustice to our entire nation and our nation's future.
    >>>>> Here are some scientific studies that you may find helpful. There
    >>>>> are a lot of good books out there, but there are a lot of quacks
    >>>>> also. The only book I truly recommend for good evidence is "Mold &
    >>>>> Mycotoxins," by Dr. Kaye H. Kilburn, M.D.
    >>>>> She worked very closely with Dr. Dorr Dearborn (Case Western
    >>>>> University/Children's Hospital, Cleveland, Ohio)who is famous for
    >>>>> finding a link between pulmonary hemorrage in infants and mold
    >>>>> exposure. Both are reknowned for their work in the area of mold
    >>>>> treatment and studies.
    >>>>> I have a copy of the testimony Dr. Stephen C. Redd, from the CDC and
    >>>>> The Department of Health and Human Services gave before Congress
    >>>>> saying that mold can cause health problems. I would be happy to send
    >>>>> it to anyone that is interested. These studies may be difficult to
    >>>>> read and very lengthy. I would love to pass them on to anyone that
    >>>>> would like to have copies. Anyone that wants to contact me can email
    >>>>> me at Thank you for taking the time to
    >>>>> read this.
    >>>>> Angie
    >>>>> A FEW STUDIES:
    >>>>> Indoor mold exposure associated with neurobehavioral and
    >>>>> pulmonary impairment: a preliminary report
    >>>>> by PubMed
    >>>>> Kilburn KH.
    >>>>> University of Southern California, Keck School of Medicine,
    >>>>> Environmental Sciences
    >>>>> Laboratory, Alhambra, California 91803, USA.
    >>>>> Recently, patients who have been exposed indoors to mixed molds,
    >>>>> spores, and
    >>>>> mycotoxins have reported asthma, airway irritation and bleeding,
    >>>>> dizziness, and
    >>>>> impaired memory and concentration, all of which suggest the presence
    >>>>> of pulmonary
    >>>>> and neurobehavioral problems. The author evaluated whether such
    >>>>> patients had
    >>>>> measurable pulmonary and neurobehavioral impairments by comparing
    >>>>> consecutive
    >>>>> cases in a series vs. a referent group. Sixty-five consecutive
    >>>>> outpatients exposed to
    >>>>> mold in their respective homes in Arizona, California, and Texas were
    >>>>> compared with
    >>>>> 202 community subjects who had no known mold or chemical exposures.
    >>>>> Balance,
    >>>>> choice reaction time, color discrimination, blink reflex, visual
    >>>>> fields, grip, hearing,
    >>>>> problem-solving, verbal recall, perceptual motor speed, and memory
    >>>>> were
    >>>>> measured. Medical histories, mood states, and symptom frequencies
    >>>>> were recorded
    >>>>> with checklists, and spirometry was used to measure various pulmonary
    >>>>> volumes
    >>>>> and flows. Neurobehavioral comparisons were made after individual
    >>>>> measurements
    >>>>> were adjusted for age, educational attainment, and sex. Significant
    >>>>> differences
    >>>>> between groups were assessed by analysis of variance; a p value of
    >>>>> less than 0.05
    >>>>> was used for all statistical tests. The mold-exposed group exhibited
    >>>>> decreased
    >>>>> function for balance, reaction time, blink-reflex latency, color
    >>>>> discrimination, visual
    >>>>> fields, and grip, compared with referents. The exposed group's scores
    >>>>> were reduced
    >>>>> for the following tests: digit-symbol substitution, peg placement,
    >>>>> trail making, verbal
    >>>>> recall, and picture completion. Twenty-one of 26 functions tested
    >>>>> were abnormal.
    >>>>> Airway obstructions were found, and vital capacities were reduced.
    >>>>> Mood state scores
    >>>>> and symptom frequencies were elevated. The author concluded that
    >>>>> indoor mold
    >>>>> exposures were associated with neurobehavioral and pulmonary
    >>>>> impairments that
    >>>>> likely resulted from the presence of mycotoxins, such as
    >>>>> trichothecenes.
    >>>>> Publication Types:
    >>>>> • Clinical Trial
    >>>>> • Controlled Clinical Trial
    >>>>> • Randomized Controlled Trial
    >>>>> PMID: 15143851 [PubMed - indexed for MEDLINE]
    >>>>> *********************************************************
    >>>>> 1: Arch Environ Health. 2003 Aug;58(8):464-74. Related
    >>>> Articles,
    >>>>> Links
    >>>>> Neural autoantibodies and neurophysiologic abnormalities in patients
    >>>>> exposed to molds in water-damaged buildings.
    >>>>> Campbell AW, Thrasher JD, Madison RA, Vojdani A, Gray MR, Johnson A.
    >>>>> Medical Center for Immune and Toxic Disorders, Spring, Texas 77386,
    >>>>> USA.
    >>>>> Adverse health effects of fungal bioaerosols on occupants of water-
    >>>>> damaged homes and other buildings have been reported. Recently, it
    >>>>> has been suggested that mold exposure causes neurological injury. The
    >>>>> authors investigated neurological antibodies and neurophysiological
    >>>>> abnormalities in patients exposed to molds at home who developed
    >>>>> symptoms of peripheral neuropathy (i.e., numbness, tingling, tremors,
    >>>>> and muscle weakness in the extremities). Serum samples were collected
    >>>>> and analyzed with the enzyme-linked immunosorbent assay (ELISA)
    >>>>> technique for antibodies to myelin basic protein, myelin-associated
    >>>>> glycoprotein, ganglioside GM1, sulfatide, myelin oligodendrocyte
    >>>>> glycoprotein, alpha-B-crystallin, chondroitin sulfate, tubulin, and
    >>>>> neurofilament. Antibodies to molds and mycotoxins were also
    >>>>> determined with ELISA, as reported previously. Neurophysiologic
    >>>>> evaluations for latency, amplitude, and velocity were performed on 4
    >>>>> motor nerves (median, ulnar, peroneal, and tibial), and for latency
    >>>>> and amplitude on 3 sensory nerves (median, ulnar, and sural).
    >>>>> Patients with documented, measured exposure to molds had elevated
    >>>>> titers of antibodies (immunoglobulin [Ig]A, IgM, and IgG) to neural-
    >>>>> specific antigens. Nerve conduction studies revealed 4 patient
    >>>>> groupings: (1) mixed sensory-motor polyneuropathy (n = 55, abnormal),
    >>>>> (2) motor neuropathy (n = 17, abnormal), (3) sensory neuropathy (n =
    >>>>> 27, abnormal), and (4) those with symptoms but no neurophysiological
    >>>>> abnormalities (n = 20, normal controls). All groups showed
    >>>>> significantly increased autoantibody titers for all isotypes (IgA,
    >>>>> IgM, and IgG) of antibodies to neural antigens when compared with 500
    >>>>> healthy controls. Groups 1 through 3 also exhibited abnormal
    >>>>> neurophysiologic findings. The authors concluded that exposure to
    >>>>> molds in water-damaged buildings increased the risk for development
    >>>>> of neural autoantibodies, peripheral neuropathy, and neurophysiologic
    >>>>> abnormalities in exposed individuals.
    >>>>> PMID: 15259425 [PubMed - indexed for MEDLINE]
    >>>>> ********************************************************
    >>>>> Show:
    >>>>> 1: Arch Environ Health. 2003 Aug;58(8):452-63. Related
    >>>> Articles,
    >>>>> Links
    >>>>> Psychological, neuropsychological, and electrocortical effects of
    >>>>> mixed mold exposure.
    >>>>> Crago BR, Gray MR, Nelson LA, Davis M, Arnold L, Thrasher JD.
    >>>>> Neurobehavioral Health Services, Tucson, Arizona 85712, USA.
    >>>>> The authors assessed the psychological, neuropsychological, and
    >>>>> electrocortical effects of human exposure to mixed colonies of
    >>>>> toxigenic molds. Patients (N = 182) with confirmed mold-exposure
    >>>>> history completed clinical interviews, a symptom checklist (SCL-90-
    >>>>> R), limited neuropsychological testing, quantitative
    >>>>> electroencephalogram (QEEG) with neurometric analysis, and measures
    >>>>> of mold exposure. Patients reported high levels of physical,
    >>>>> cognitive, and emotional symptoms. Ratings on the SCL-90-R
    >>>>> were "moderate" to "severe," with a factor reflecting situational
    >>>>> depression accounting for most of the variance. Most of the patients
    >>>>> were found to suffer from acute stress, adjustment disorder, or post-
    >>>>> traumatic stress. Differential diagnosis confirmed an etiology of a
    >>>>> combination of external stressors, along with organic metabolically
    >>>>> based dysregulation of emotions and decreased cognitive functioning
    >>>>> as a result of toxic or metabolic encephalopathy. Measures of toxic
    >>>>> mold exposure predicted QEEG measures and neuropsychological test
    >>>>> performance. QEEG results included narrowed frequency bands and
    >>>>> increased power in the alpha and theta bands in the frontal areas of
    >>>>> the cortex. These findings indicated a hypoactivation of the frontal
    >>>>> cortex, possibly due to brainstem involvement and insufficient
    >>>>> excitatory input from the reticular activating system.
    >>>>> Neuropsychological testing revealed impairments similar to mild
    >>>>> traumatic brain injury. In comparison with premorbid estimates of
    >>>>> intelligence, findings of impaired functioning on multiple cognitive
    >>>>> tasks predominated. A dose-response relationship between measures of
    >>>>> mold exposure and abnormal neuropsychological test results and QEEG
    >>>>> measures suggested that toxic mold causes significant problems in
    >>>>> exposed individuals. Study limitations included lack of a comparison
    >>>>> group, patient selection bias, and incomplete data sets that did not
    >>>>> allow for comparisons among variables.
    >>>>> PMID: 15259424 [PubMed - indexed for MEDLINE]
    >>>>> ****************************************************
    >>>>> 1: ScientificWorldJournal. 2003 Nov 3;3:1058-64. Print 2003 Nov 3.
    >>>>> Related Articles, Links
    >>>>> Biochemical changes in the serum of patients with chronic toxigenic
    >>>>> mold exposures: a risk factor for multiple renal dysfunctions.
    >>>>> Anyanwu E, Campbell AW, Vojdani A, Ehiri JE, Akpan AI.
    >>>>> Neurosciences Research, Cahers Inc., Conroe, TX, USA.
    >>>>> This paper analyzes and presents the biochemical abnormalities in the
    >>>>> sera of patients presenting with chronic mycosis in order to
    >>>>> investigate the relationship with the risks of multiple renal
    >>>>> disorders. The study population (n = 10) consisted of six females and
    >>>>> four males (mean age 36.3 years) exposed by toxic molds in their
    >>>>> homes and offices for an average of 2.8 years. The control group
    >>>>> comprised ten people, five males and five females (mean age 35.9
    >>>>> years) without any known exposures to toxic molds. Blood samples were
    >>>>> obtained from both the patients and the controls and were processed
    >>>>> using specific biochemical methods that included enzyme-linked
    >>>>> immunoabsorbent assay (ELISA). There were biochemical abnormal
    >>>>> concentrations in creatinine, uric acid, phosphorus, alkaline
    >>>>> phosphotase, cholesterol, HDH, SGOT/AST, segmented neutrophils,
    >>>>> lymphocytes, total T3, IgG and IgA immunoglobulins with significant
    >>>>> differences between patients and controls. These abnormalities were
    >>>>> consistent with multiple renal disorders. The major complaints of the
    >>>>> mycosis patients were headaches, pulmonary symptoms, allergic
    >>>>> reactions, memory loss, skin rashes, blurred vision symptoms,
    >>>>> fatigue, and runny nose. These findings were depictive of a strong
    >>>>> association of chronic mycosis with abnormal renal indicators. It was
    >>>>> concluded that, although this research was a pilot investigation,
    >>>>> based on the overall results, people exposed to chronic indoor
    >>>>> environmental toxic molds were at risk of multiple renal
    >>>>> complications.
    >>>>> PMID: 14612611 [PubMed - indexed for MEDLINE]
    >>>>> *****************************************************
    >>>>> 1: Arch Environ Health. 2003 Jul;58(7):442-6. Related
    >>> Articles,
    >>>>> Links
    >>>>> Health symptoms caused by molds in a courthouse.
    >>>>> Lee TG.
    >>>>> Faculty of Environmental Design, The University of Calgary, Calgary,
    >>>>> Alberta, Canada.
    >>>>> A majority of occupants of a newly renovated historic courthouse in
    >>>>> Calgary, Alberta, Canada, reported multiple (3 or more) health-
    >>>>> related symptoms, and several reported more than 10 persistent
    >>>>> symptoms. Most required at least 1 day outside of the building to
    >>>>> recover from their symptoms. Molds that produce mycotoxins, such as
    >>>>> Stachybotrys chartarum and Emericella nidulans, were identified in
    >>>>> the building, along with fungal organisms of the genera Aspergillus,
    >>>>> Penicillium, Streptomyces, Cladosporium, Chaetomium, Rhizopus/Mucor,
    >>>>> Alternaria, Ulocladium, and Basidiomycetes. Renovations to this
    >>>>> historic had building failed to provide adequate thermal and vapor
    >>>>> barriers, thus allowing moist indoor air to migrate into the building
    >>>>> enclosure, causing condensation to develop. Mold grew on the
    >>>>> condensation and was dispersed throughout the courthouse, including
    >>>>> on furniture and files. The courthouse was closed and a new facility
    >>>>> was modified with low-offgassing materials, better ventilation and
    >>>>> air filtration, and strict building maintenance to accommodate those
    >>>>> occupants of the older building who had developed multiple chemical
    >>>>> sensitivities.
    >>>>> PMID: 15143857 [PubMed - indexed for MEDLINE]
    >>>>> **************************************************
    >>>>> Abstract: Identifying markers for chronic illness in pediatric
    >>>>> patients exposed to water damaged buildings: Linkage disequilibrium
    >>>>> of HLA DR, MSH, MMP9 and autoantibodies
    >>>>> Authors: Ritchie C. Shoemaker¹, Courtney Holt¹, Dennis House¹, HK
    >>>>> Hudnell²
    >>>>> ¹Center for Research on Biotoxin Associated Illnesses, Pocomoke, Md;
    >>>>> ²US EPA NHEERL, Research Triangle Park, NC
    >>>>> Background: No studies have previously identified biomarkers
    >>>>> adequate to create a case definition of illness associated with
    >>>>> exposure to water damaged buildings (WDB) in pediatric patients.
    >>>>> Previous work from this facility has presented a case definition of
    >>>>> illness in adults that includes exposure, symptoms and absence of
    >>>>> confounders, together with biomarkers HLA DR genotypes of the immune
    >>>>> response genes; deficiency of the hypothalamic immunomodulatory
    >>>>> hormone, alpha melanocyte stimulating hormone (MSH); excess pro-
    >>>>> inflammatory cytokine responses, represented by matrix
    >>>>> metalloproteinase-9 (MMP9), deficits in visual contrast and pituitary
    >>>>> hormone dysregulation. We have seen an increased incidence of
    >>>>> antibodies to gliadin, cardiolipin and myelin basic protein in adults
    >>>>> with chronic illness following exposure to WDB. Here we present data
    >>>>> supporting a pediatric case definition using multiple biomarkers from
    >>>>> 66 patients with illness following exposure to WDB.
    >>>>> Methods: Patients under age 19 coming for treatment of chronic
    >>>>> illness at a specialized medical clinic provided informed consent for
    >>>>> evaluation and blood testing prior to initiation of definitive
    >>>>> therapy for presumptive chronic, biotoxin associated illness.
    >>>>> Symptoms were recorded and blood was sent to national high complexity
    >>>>> labs for analysis of HLA DR genotype, MSH, MMP9, anticardiolipins
    >>>>> (ACLA), antigliadins (AGA) and myelin basic protein (MBP) antibodies.
    >>>>> Lab parameters were compared to in-house registries of control
    >>>>> patients and published registries. Following treatment and
    >>>>> confirmation of diagnosis, cases were then analyzed by biomarker to
    >>>>> identify unique diagnostic features.
    >>>>> Results: Control populations have markedly different HLA DR genotype
    >>>>> distributions from cases, with relative risks for illness identified
    >>>>> for the same genotypes as reported previously in adults. Affected
    >>>>> patients had lower levels of MSH and MMP9 than controls. Marked
    >>>>> increase in incidence of antibodies to antigliadin IgG,
    >>>>> anticardiolipin IgM and myelin basic protein antibodies was found in
    >>>>> affected patients compared to controls. Taken together, the
    >>>>> combination of potential for exposure, absence of confounding
    >>>>> diagnoses, presence of distinctive groupings of symptoms, including
    >>>>> fatigue and cognitive problems identified over 85&37; of cases.
    >>>> Adding
    >>>>> HLA DR, MSH deficiency, AGA-IgG and ACLA-IgM increased the case
    >>>>> detection rate to 100&37;. For patients with MMP9 over 400, HLA DR
    >>>> and
    >>>>> MSH deficiency alone identified all cases.
    >>>>> Conclusion: Specific genetic, physiologic and neurotoxicologic
    >>>>> factors can be identified in pediatric patients that identify cases
    >>>>> of chronic illness due to exposure to WDB. Physiologic mechanisms
    >>>>> associated with increased production of particular autoantibodies
    >>>>> will require further study.

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