Follow us!

    Re: Abstract of Study - Discuss This

    Posted by ff on 2/05/08

    Mike B.:

    Make that reference # 84. Thanks for the reference.


    On 2/05/08, Mike B. wrote:
    > Stachybotrys chartarum, Trichothecene Mycotoxins, and Damp
    > Building-Related Illness: New Insights into a Public
    > Enigma.
    > Pestka JJ, Yike I, Dearborn DG, Ward MD, Harkema JR.
    > Center for Integrative Toxicology.
    > Damp building-related illnesses (DRBI) include a myriad of
    > respiratory, immunologic and neurologic symptoms that are
    > sometimes etiologically linked to aberrant indoor growth
    > the toxic black mold, Stachybotrys chartarum. Although
    > supportive evidence for such linkages are limited, there
    > are exciting new findings about this enigmatic organism
    > relative to its environmental dissemination, novel
    > bioactive components, unique cellular targets and
    > mechanisms of action which provide insight into the S.
    > chartarum's potential to evoke allergic sensitization,
    > inflammation and cytotoxicity in the upper and lower
    > respiratory tracts. Macrocyclic trichothecene mycotoxins,
    > produced by one chemotype of this fungus, are potent
    > translational inhibitors and stress kinase activators that
    > appear to be a critical underlying cause for a number of
    > adverse effects. Notably, these toxins form covalent
    > protein adducts in vitro and in vivo and, furthermore,
    > cause neurotoxicity and inflammation in the nose and brain
    > of the mouse. A second S.chartarum chemotype has recently
    > been shown to produce atranones - mycotoxins that can
    > induce pulmonary inflammation. Other biologically active
    > products of this fungus that might contribute to
    > pathophysiologic effects include proteinases, hemolysins,
    > beta-glucan and spirocyclic drimanes. Solving the enigma
    > whether Stachybotrys inhalation indeed contributes to DRBI
    > will require studies of the pathophysiologic effects of
    > dose chronic exposure to well-characterized, standardized
    > preparations of S. chartarum spores and mycelial
    > and, co-exposures with other environmental cofactors. Such
    > studies must be linked to improved assessments of human
    > exposure to this fungus and its bioactive constituents in
    > indoor air using both state-of-the-art sampling/analytical
    > methods and relevant biomarkers.

    Posts on this thread, including this one

  Site Map:  Home Chatboards Legal Jobs Classified Ads Search Contacts Advertise
  © 1996 - 2013. All Rights Reserved. Please review our Terms of Use, Mission Statement, and Privacy Policy.